| 311* | HM Amla | South Africa v England | The Kia Oval, Kennington | 2012 |
| 278* | AB de Villiers | South Africa v Pakistan | Sheikh Zayed Stadium, Abu Dhabi | 2010/11 |
| 277 | GC Smith | South Africa v England | Edgbaston, Birmingham | 2003 |
| 275* | DJ Cullinan | South Africa v New Zealand | Eden Park, Auckland | 1998/99 |
| 275 | G Kirsten | South Africa v England | Kingsmead, Durban | 1999/00 |
| 274 | RG Pollock | South Africa v Australia | Kingsmead, Durban | 1969/70 |
| 259 | GC Smith | South Africa v England | Lord's Cricket Ground, St John's Wood | 2003 |
| 255* | DJ McGlew | South Africa v New Zealand | Basin Reserve, Wellington | 1952/53 |
| 253* | HM Amla | South Africa v India | Vidarbha Cricket Association Stadium, Nagpur | 2009/10 |
| 236 | EAB Rowan | South Africa v England | Headingley, Leeds | 1951 |
| 234 | GC Smith | South Africa v Pakistan | Dubai Sports City Stadium, Dubai | 2013/14 |
| 232 | GC Smith | South Africa v Bangladesh | Bir Shrestha Shahid Ruhul Amin Stadium, Chittagong | 2007/08 |
| 231 | AD Nourse | South Africa v Australia | Old Wanderers, Johannesburg | 1935/36 |
| 228 | HH Gibbs | South Africa v Pakistan | Newlands, Cape Town | 2002/03 |
| 226 | ND McKenzie | South Africa v Bangladesh | Bir Shrestha Shahid Ruhul Amin Stadium, Chittagong | 2007/08 |
| 224 | JH Kallis | South Africa v Sri Lanka | Sahara Park Newlands, Cape Town | 2011/12 |
| 222* | JA Rudolph | South Africa v Bangladesh | MA Aziz Stadium, Chittagong | 2003 |
| 220 | G Kirsten | South Africa v Zimbabwe | Harare Sports Club, Harare | 2001/02 |
| 217* | AB de Villiers | South Africa v India | Sardar Patel Stadium, Motera, Ahmedabad | 2007/08 |
| 211* | HH Gibbs | South Africa v New Zealand | Jade Stadium, Christchurch | 1998/99 |
| 210 | G Kirsten | South Africa v England | Old Trafford, Manchester | 1998 |
| 209 | RG Pollock | South Africa v Australia | Newlands, Cape Town | 1966/67 |
| 208 | AD Nourse | South Africa v England | Trent Bridge, Nottingham | 1951 |
| 208 | HM Amla | South Africa v West Indies | SuperSport Park, Centurion | 2014/15 |
| 204 | GA Faulkner | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 1910/11 |
| 201 | EJ Barlow | South Africa v Australia | Adelaide Oval, Adelaide | 1963/64 |
| 201* | JH Kallis | South Africa v India | SuperSport Park, Centurion | 2010/11 |
| 201 | HM Amla | South Africa v England | PPC Newlands, Cape Town | 2015/16 |
| 200 | GC Smith | South Africa v Bangladesh | Buffalo Park, East London | 2002/03 |
| 199 | D Elgar | South Africa v Bangladesh | Senwes Park, Potchefstroom | 2017/18 |
| 199 | F du Plessis | South Africa v Sri Lanka | SuperSport Park, Centurion | 2020/21 |
