| 228 | HH Gibbs | South Africa v Pakistan | Newlands, Cape Town | 2002/03 |
| 223 | GC Smith | South Africa v Bangladesh | Bir Shrestha Shahid Ruhul Amin Stadium, Chittagong | 2007/08 |
| 202 | G Kirsten | South Africa v Zimbabwe | Harare Sports Club, Harare | 2001/02 |
| 200 | GC Smith | South Africa v Bangladesh | Buffalo Park, East London | 2002/03 |
| 188 | GA Faulkner | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 1910/11 |
| 188 | B Mitchell | South Africa v England | Kennington Oval, Kennington | 1947 |
| 183 | A Melville | South Africa v England | Trent Bridge, Nottingham | 1947 |
| 183 | HH Gibbs | South Africa v England | The AMP Oval, Kennington | 2003 |
| 181 | RG Pollock | South Africa v Australia | Newlands, Cape Town | 1966/67 |
| 179 | HH Gibbs | South Africa v England | Edgbaston, Birmingham | 2003 |
| 178 | GC Smith | South Africa v England | Edgbaston, Birmingham | 2003 |
| 171 | T Bavuma | South Africa v West Indies | Imperial Wanderers Stadium, Johannesburg | 2022/23 |
| 169 | ND McKenzie | South Africa v Bangladesh | Bir Shrestha Shahid Ruhul Amin Stadium, Chittagong | 2007/08 |
| 169 | AB de Villiers | South Africa v Australia | Western Australia Cricket Association Ground, Perth | 2012/13 |
| 162 | DT Lindsay | South Africa v Australia | New Wanderers Stadium, Johannesburg | 1966/67 |
| 162 | GC Smith | South Africa v England | Sahara Park Newlands, Cape Town | 2009/10 |
| 161 | DJ Cullinan | South Africa v New Zealand | Eden Park, Auckland | 1998/99 |
| 160 | EAB Rowan | South Africa v England | Headingley, Leeds | 1951 |
| 160 | RG Pollock | South Africa v Australia | Kingsmead, Durban | 1969/70 |
| 160 | GC Smith | South Africa v Pakistan | Dubai Sports City Stadium, Dubai | 2013/14 |
| 159 | JH Kallis | South Africa v India | Vidarbha Cricket Association Stadium, Nagpur | 2009/10 |
| 159 | JH Kallis | South Africa v Sri Lanka | Sahara Park Newlands, Cape Town | 2011/12 |
| 158 | AB de Villiers | South Africa v India | Sardar Patel Stadium, Motera, Ahmedabad | 2007/08 |
| 158 | AB de Villiers | South Africa v Pakistan | Sheikh Zayed Stadium, Abu Dhabi | 2010/11 |
| 157 | AB de Villiers | South Africa v Pakistan | Dubai Sports City Stadium, Dubai | 2013/14 |
| 155 | HH Gibbs | South Africa v India | St George's Park, Port Elizabeth | 2001/02 |
| 155 | JA Rudolph | South Africa v Bangladesh | MA Aziz Stadium, Chittagong | 2003 |
| 155 | JP Duminy | South Africa v Sri Lanka | Bidvest Wanderers Stadium, Johannesburg | 2016/17 |
| 154 | G Kirsten | South Africa v Bangladesh | North West Cricket Stadium, Potchefstroom | 2002/03 |
| 154 | GC Smith | South Africa v England | Edgbaston, Birmingham | 2008 |
