| Minutes |
| 545 | DJ McGlew | South Africa v Australia | Kingsmead, Durban | 1957/58 |
| 436 | AJ Hall | South Africa v India | Modi Stadium, Kanpur | 2004/05 |
| 414 | JHB Waite | South Africa v Australia | Kingsmead, Durban | 1957/58 |
| 413 | WJ Cronje | South Africa v India | St George's Park, Port Elizabeth | 1992/93 |
| 413 | JA Rudolph | South Africa v Australia | Western Australia Cricket Association Ground, Perth | 2005/06 |
| 385 | F du Plessis | South Africa v Australia | Adelaide Oval, Adelaide | 2012/13 |
| 381 | G Kirsten | South Africa v England | Kingsmead, Durban | 1999/00 |
| 368 | AJ Pithey | South Africa v England | Newlands, Cape Town | 1964/65 |
| 360 | AD Nourse | South Africa v England | Kingsmead, Durban | 1938/39 |
| 355 | WJ Cronje | South Africa v Sri Lanka | Sinhalese Sports Club Ground, Colombo | 1993 |
| 353 | HH Dippenaar | South Africa v England | Sahara Oval St George's, Port Elizabeth | 2004/05 |
| 346 | DJ Cullinan | South Africa v Sri Lanka | P Saravanamuttu Stadium, Colombo | 1993 |
| 341 | HM Amla | South Africa v India | Eden Gardens, Kolkata | 2009/10 |
| 337 | HM Amla | South Africa v Australia | Brisbane Cricket Ground, Woolloongabba, Brisbane | 2012/13 |
| 336 | JH Kallis | South Africa v England | Sahara Park Newlands, Cape Town | 2004/05 |
| 335 | JH Kallis | South Africa v Australia | Sydney Cricket Ground, Sydney | 2005/06 |
| 333 | JH Kallis | South Africa v New Zealand | Jade Stadium, Christchurch | 1998/99 |
| 333 | HH Dippenaar | South Africa v Bangladesh | MA Aziz Stadium, Chittagong | 2003 |
| 331 | CN Frank | South Africa v Australia | Old Wanderers, Johannesburg | 1921/22 |
| 331 | JH Kallis | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 1997/98 |
| 331 | JH Kallis | South Africa v Zimbabwe | Queens Sports Club, Bulawayo | 2001/02 |
| 323 | G Kirsten | South Africa v England | Headingley, Leeds | 2003 |
| 320 | JHB Waite | South Africa v England | Old Trafford, Manchester | 1955 |
| 320 | HH Gibbs | South Africa v England | New Wanderers Stadium, Johannesburg | 2004/05 |
| 320 | AG Prince | South Africa v Australia | Sydney Cricket Ground, Sydney | 2005/06 |
