| 274 | RG Pollock | South Africa v Australia | Kingsmead, Durban | 1969/70 |
| 251 | DT Lindsay | South Africa v Australia | New Wanderers Stadium, Johannesburg | 1966/67 |
| 248 | EJ Barlow | South Africa v Australia | Adelaide Oval, Adelaide | 1963/64 |
| 231 | AD Nourse | South Africa v Australia | Old Wanderers, Johannesburg | 1935/36 |
| 213 | RG Pollock | South Africa v Australia | Newlands, Cape Town | 1966/67 |
| 212 | GA Faulkner | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 1910/11 |
| 207 | BA Richards | South Africa v Australia | St George's Park, Port Elizabeth | 1969/70 |
| 207 | HM Amla | South Africa v Australia | Western Australia Cricket Association Ground, Perth | 2012/13 |
| 196 | JH Kallis | South Africa v Australia | Brisbane Cricket Ground, Woolloongabba, Brisbane | 2012/13 |
| 189 | AK Markram | South Africa v Australia | Bidvest Wanderers Stadium, Johannesburg | 2017/18 |
| 188 | F du Plessis | South Africa v Australia | Adelaide Oval, Adelaide | 2012/13 |
| 185 | G Kirsten | South Africa v Australia | Adelaide Oval, Adelaide | 1997/98 |
| 179 | AD Nourse | South Africa v Australia | Newlands, Cape Town | 1949/50 |
| 175 | AW Nourse | South Africa v Australia | Old Wanderers, Johannesburg | 1921/22 |
| 175 | RG Pollock | South Africa v Australia | Adelaide Oval, Adelaide | 1963/64 |
| 175 | AK Markram | South Africa v Australia | Sahara Stadium Kingsmead, Durban | 2017/18 |
| 174 | JHB Waite | South Africa v Australia | New Wanderers Stadium, Johannesburg | 1957/58 |
| 173 | AB de Villiers | South Africa v Australia | Western Australia Cricket Association Ground, Perth | 2012/13 |
| 171 | GA Faulkner | South Africa v Australia | Adelaide Oval, Adelaide | 1910/11 |
| 171 | G Kirsten | South Africa v Australia | Sydney Cricket Ground, Sydney | 2001/02 |
| 170 | B Mitchell | South Africa v Australia | Adelaide Oval, Adelaide | 1931/32 |
| 169 | AB de Villiers | South Africa v Australia | Western Australia Cricket Association Ground, Perth | 2008/09 |
| 166 | JP Duminy | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 2008/09 |
| 165 | JW Zulch | South Africa v Australia | Sydney Cricket Ground, Sydney | 1910/11 |
| 164 | WR Endean | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 1952/53 |
| 164 | TL Goddard | South Africa v Australia | Sydney Cricket Ground, Sydney | 1963/64 |
| 164 | RG Pollock | South Africa v Australia | Sydney Cricket Ground, Sydney | 1963/64 |
| 163 | EJ Barlow | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 1963/64 |
| 163 | AB de Villiers | South Africa v Australia | Sahara Park Newlands, Cape Town | 2008/09 |
| 162 | HW Taylor | South Africa v Australia | Adelaide Oval, Adelaide | 1931/32 |
