| Runs |
Wkts |
| 434 | 11 | Durham v Lancashire | Seat Unique Riverside Ground, Chester-le-Street | 2024 |
| 422 | 11 | Warwickshire v Durham | Edgbaston, Birmingham | 2018 |
| 417 | 12 | Yorkshire v Durham | Headingley, Leeds | 2022 |
| 415 | 13 | Warwickshire v Durham | Edgbaston, Birmingham | 2010 |
| 415 | 13 | Northamptonshire v Durham | County Ground, Northampton | 2022 |
| 413 | 15 | Durham v Nottinghamshire | Banks Homes Riverside, Chester-le-Street | 2025 |
| 412 | 14 | Worcestershire v Durham | County Ground, New Road, Worcester | 2016 |
| 407 | 6 | Durham v Northamptonshire | Banks Homes Riverside, Chester-le-Street | 2025 |
| 406 | 10 | Yorkshire v Durham | Headingley, Leeds | 2023 |
| 405 | 4 | Worcestershire v Durham | County Ground, New Road, Worcester | 2017 |
| 397 | 14 | Yorkshire v Durham | Headingley, Leeds | 2016 |
| 394 | 8 | Durham v Northamptonshire | Emirates Durham International Cricket Ground, Chester-le-Street | 2014 |
| 392 | 10 | Lancashire v Durham | Emirates Old Trafford, Manchester | 2021 |
| 391 | 7 | Durham v Derbyshire | Emirates Riverside, Chester-le-Street | 2020 |
| 389 | 14 | Worcestershire v Durham | Blackfinch New Road, Worcester | 2018 |
| 387 | 10 | Derbyshire v Durham | The Incora County Ground, Derby | 2022 |
| 385 | 11 | Yorkshire v Durham | Headingley, Leeds | 2015 |
| 380 | 15 | Leicestershire v Durham | Uptonsteel County Ground, Leicester | 2025 |
| 379 | 11 | Lancashire v Durham | Old Trafford, Manchester | 2005 |
| 379 | 12 | Durham v Leicestershire | Emirates Durham International Cricket Ground, Chester-le-Street | 2010 |
| 379 | 10 | Nottinghamshire v Durham | Trent Bridge, Nottingham | 2012 |
| 377 | 13 | Durham v Nottinghamshire | Emirates Riverside, Chester-le-Street | 2021 |
| 373 | 11 | Durham v Derbyshire | Emirates Riverside, Chester-le-Street | 2016 |
| 372 | 14 | Nottinghamshire v Durham | Trent Bridge, Nottingham | 2011 |
| 371 | 12 | Durham v Leicestershire | Emirates Durham International Cricket Ground, Chester-le-Street | 2011 |
| 367 | 12 | Nottinghamshire v Durham | Trent Bridge, Nottingham | 2017 |
| 367 | 13 | Durham v Yorkshire | Emirates Riverside, Chester-le-Street | 2020 |
| 367 | 14 | Nottinghamshire v Durham | Trent Bridge, Nottingham | 2022 |
| 366 | 7 | Durham v Nottinghamshire | Emirates Riverside, Chester-le-Street | 2020 |
| 365 | 9 | Worcestershire v Durham | Blackfinch New Road, Worcester | 2019 |
