| Runs |
Out of |
4s |
6s |
| 84 | 110* | 15 | 4 | | RE Levi | Northamptonshire v Gloucestershire | College Ground, Cheltenham | 2013 |
| 82 | 110* | 13 | 5 | | CA Lynn | Northamptonshire v Leicestershire | County Ground, Northampton | 2023 |
| 88 | 100 | 7 | 10 | | DJ Willey | Northamptonshire v Sussex | The Brighton and Hove Jobs County Ground, Hove | 2015 |
| 86 | 113* | 8 | 9 | | CA Lynn | Northamptonshire v Worcestershire | County Ground, Northampton | 2022 |
| 76 | 111* | 10 | 6 | | L Klusener | Northamptonshire v Worcestershire | Chester Road North, Kidderminster | 2007 |
| 76 | 88 | 7 | 8 | | RE Levi | Northamptonshire v Nottinghamshire | Trent Bridge, Nottingham | 2017 |
| 66 | 96 | 12 | 3 | | BM Duckett | Northamptonshire v Leicestershire | County Ground, Northampton | 2018 |
| 66 | 106* | 12 | 3 | | CA Lynn | Northamptonshire v Leicestershire | County Ground, Northampton | 2022 |
| 68 | 95 | 8 | 6 | | DJ Willey | Northamptonshire v Leicestershire | County Ground, Northampton | 2014 |
| 62 | 85 | 11 | 3 | | AM Rossington | Northamptonshire v Warwickshire | County Ground, Northampton | 2016 |
| 60 | 84 | 12 | 2 | | BM Duckett | Northamptonshire v Nottinghamshire | Edgbaston, Birmingham | 2016 |
| 68 | 95* | 8 | 6 | | RE Levi | Northamptonshire v Warwickshire | Edgbaston, Birmingham | 2018 |
| 68 | 103 | 8 | 6 | | JJ Cobb | Northamptonshire v Warwickshire | County Ground, Northampton | 2018 |
| 70 | 79 | 7 | 7 | | DJ Willey | Northamptonshire v Nottinghamshire | Trent Bridge, Nottingham | 2024 |
| 62 | 94 | 11 | 3 | | MP Breetzke | Northamptonshire v Derbyshire | The Incora County Ground, Derby | 2024 |
| 68 | 86 | 8 | 6 | | SA Zaib | Northamptonshire v Warwickshire | County Ground, Northampton | 2024 |
| 66 | 93 | 9 | 5 | | MP Breetzke | Northamptonshire v Derbyshire | County Ground, Northampton | 2025 |
| 58 | 80 | 10 | 3 | | JJ Cobb | Northamptonshire v Durham | Edgbaston, Birmingham | 2016 |
| 60 | 88 | 9 | 4 | | BM Duckett | Northamptonshire v Nottinghamshire | County Ground, Northampton | 2018 |
| 60 | 80* | 9 | 4 | | PR Stirling | Northamptonshire v Worcestershire | Blackfinch New Road, Worcester | 2020 |
| 54 | 71 | 12 | 1 | | BJ Curran | Northamptonshire v Durham | County Ground, Northampton | 2022 |
| 58 | 74 | 10 | 3 | | SA Zaib | Northamptonshire v Warwickshire | County Ground, Northampton | 2022 |
| 52 | 65 | 13 | 0 | | RS Vasconcelos | Northamptonshire v Warwickshire | County Ground, Northampton | 2023 |
| 64 | 85 | 7 | 6 | | MP Breetzke | Northamptonshire v Warwickshire | Edgbaston, Birmingham | 2025 |
| 50 | 88 | 11 | 1 | | MEK Hussey | Northamptonshire v Somerset | County Ground, Northampton | 2003 |
| 50 | 73 | 11 | 1 | | WPUJC Vaas | Northamptonshire v Durham | County Ground, Northampton | 2010 |
| 54 | 92* | 9 | 3 | | BM Duckett | Northamptonshire v Worcestershire | County Ground, New Road, Worcester | 2017 |
| 50 | 62 | 11 | 1 | | BJ Curran | Northamptonshire v Durham | County Ground, Northampton | 2021 |
| 64 | 83 | 4 | 8 | | CA Lynn | Northamptonshire v Durham | County Ground, Northampton | 2022 |
| 56 | 92 | 8 | 4 | | SA Zaib | Northamptonshire v Derbyshire | The Incora County Ground, Derby | 2022 |
| 58 | 76 | 7 | 5 | | MP Breetzke | Northamptonshire v Lancashire | Emirates Old Trafford, Manchester | 2024 |
| 58 | 84* | 7 | 5 | | RS Bopara | Northamptonshire v Derbyshire | The Central Co-op County Ground, Derby | 2025 |
