| Runs |
Wkts |
| 462 | 10 | Warwickshire v Northamptonshire | Edgbaston, Birmingham | 2018 |
| 449 | 9 | Worcestershire v Northamptonshire | Chester Road North, Kidderminster | 2007 |
| 437 | 9 | Northamptonshire v Leicestershire | County Ground, Northampton | 2018 |
| 427 | 13 | Leicestershire v Northamptonshire | Uptonsteel County Ground, Leicester | 2022 |
| 424 | 10 | Northamptonshire v Warwickshire | County Ground, Northampton | 2022 |
| 418 | 10 | Somerset v Northamptonshire | County Ground, Taunton | 2004 |
| 416 | 12 | Northamptonshire v Leicestershire | County Ground, Northampton | 2024 |
| 415 | 13 | Northamptonshire v Durham | County Ground, Northampton | 2022 |
| 414 | 14 | Northamptonshire v Nottinghamshire | County Ground, Northampton | 2021 |
| 413 | 8 | Northamptonshire v Somerset | County Ground, Northampton | 2024 |
| 412 | 10 | Northamptonshire v Leicestershire | County Ground, Northampton | 2022 |
| 408 | 10 | Northamptonshire v Worcestershire | County Ground, Northampton | 2015 |
| 404 | 15 | Lancashire v Northamptonshire | Emirates Old Trafford, Manchester | 2024 |
| 396 | 14 | Yorkshire v Northamptonshire | Headingley, Leeds | 2017 |
| 395 | 9 | Gloucestershire v Northamptonshire | College Ground, Cheltenham | 2013 |
| 394 | 8 | Durham v Northamptonshire | Emirates Durham International Cricket Ground, Chester-le-Street | 2014 |
| 392 | 14 | Northamptonshire v Derbyshire | County Ground, Northampton | 2016 |
| 391 | 12 | Northamptonshire v Derbyshire | County Ground, Northampton | 2018 |
| 390 | 12 | Northamptonshire v Glamorgan | County Ground, Northampton | 2008 |
| 384 | 14 | Worcestershire v Northamptonshire | County Ground, New Road, Worcester | 2015 |
| 384 | 12 | Warwickshire v Northamptonshire | Edgbaston, Birmingham | 2020 |
| 383 | 12 | Northamptonshire v Derbyshire | County Ground, Northampton | 2014 |
| 383 | 13 | Northamptonshire v Warwickshire | County Ground, Northampton | 2023 |
| 383 | 12 | Northamptonshire v Warwickshire | County Ground, Northampton | 2024 |
| 380 | 10 | Somerset v Northamptonshire | County Ground, Taunton | 2005 |
| 380 | 16 | Northamptonshire v Nottinghamshire | County Ground, Northampton | 2018 |
| 379 | 11 | Somerset v Northamptonshire | County Ground, Taunton | 2006 |
| 378 | 11 | Derbyshire v Northamptonshire | The Incora County Ground, Derby | 2022 |
| 377 | 11 | Somerset v Northamptonshire | County Ground, Taunton | 2008 |
| 377 | 8 | Northamptonshire v Worcestershire | County Ground, Northampton | 2019 |
| 377 | 17 | Northamptonshire v Worcestershire | County Ground, Northampton | 2023 |
