| 188* | G Kirsten | South Africa v United Arab Emirates | Rawalpindi Cricket Stadium, Rawalpindi | 1995/96 |
| 185 | F du Plessis | South Africa v Sri Lanka | PPC Newlands, Cape Town | 2016/17 |
| 178 | Q de Kock | South Africa v Australia | SuperSport Park, Centurion | 2016/17 |
| 177* | JN Malan | South Africa v Ireland | The Village, Malahide, Dublin | 2021 |
| 176 | AB de Villiers | South Africa v Bangladesh | Eurolux Boland Park, Paarl | 2017/18 |
| 175 | HH Gibbs | South Africa v Australia | Liberty Life Wanderers Stadium, Johannesburg | 2005/06 |
| 175 | AK Markram | South Africa v Netherlands | Imperial Wanderers Stadium, Johannesburg | 2023 |
| 174 | H Klaasen | South Africa v Australia | SuperSport Park, Centurion | 2023/24 |
| 174 | Q de Kock | South Africa v Bangladesh | Wankhede Stadium, Mumbai | 2023/24 |
| 169* | DJ Callaghan | South Africa v New Zealand | Centurion Park, Verwoerdburg | 1994/95 |
| 168* | Q de Kock | South Africa v Bangladesh | De Beers Diamond Oval, Kimberley | 2017/18 |
| 162* | AB de Villiers | South Africa v West Indies | Sydney Cricket Ground, Sydney | 2014/15 |
| 161 | AC Hudson | South Africa v Netherlands | Rawalpindi Cricket Stadium, Rawalpindi | 1995/96 |
| 159 | HM Amla | South Africa v Ireland | Manuka Oval, Canberra | 2014/15 |
| 154 | HM Amla | South Africa v Sri Lanka | SuperSport Park, Centurion | 2016/17 |
| 153 | HH Gibbs | South Africa v Bangladesh | North West Cricket Stadium, Potchefstroom | 2002/03 |
| 153* | HM Amla | South Africa v West Indies | Bidvest Wanderers Stadium, Johannesburg | 2014/15 |
| 150 | HM Amla | South Africa v England | The Ageas Bowl, Southampton | 2012 |
| 150* | JP Duminy | South Africa v Netherlands | VRA Ground, Amstelveen | 2013 |
| 150 | MP Breetzke | South Africa v New Zealand | Gaddafi Stadium, Lahore | 2024/25 |
| 149 | AB de Villiers | South Africa v West Indies | Bidvest Wanderers Stadium, Johannesburg | 2014/15 |
| 147* | MV Boucher | South Africa v Zimbabwe | Sedgars Park, Potchefstroom | 2006/07 |
| 146 | AB de Villiers | South Africa v West Indies | Queen's Park (New), St George's | 2006/07 |
| 144 | T Bavuma | South Africa v West Indies | Buffalo Park, East London | 2022/23 |
| 143 | HH Gibbs | South Africa v New Zealand | New Wanderers Stadium, Johannesburg | 2002/03 |
| 141 | GC Smith | South Africa v England | SuperSport Park, Centurion | 2009/10 |
| 140 | HM Amla | South Africa v Bangladesh | Willowmoore Park Main Oval, Benoni | 2008/09 |
| 139 | JH Kallis | South Africa v West Indies | New Wanderers Stadium, Johannesburg | 2003/04 |
| 139 | DA Miller | South Africa v Australia | Blundstone Arena, Hobart | 2018/19 |
| 138* | DA Miller | South Africa v Zimbabwe | Seddon Park, Hamilton | 2014/15 |
| 138* | Q de Kock | South Africa v England | Mangaung Oval, Bloemfontein | 2015/16 |
