| 0-221 | N Boje | South Africa v Sri Lanka | Sinhalese Sports Club Ground, Colombo | 2006 |
| 3-203 | PL Harris | South Africa v India | MA Chidambaram Stadium, Chepauk, Chennai | 2007/08 |
| 1-196 | KA Maharaj | South Africa v India | Maharashtra Cricket Association Stadium, Gahunje | 2019/20 |
| 3-189 | KA Maharaj | South Africa v India | Dr YS Rajasekhara Reddy ACA-VDCA Cricket Stadium, Visakhapatnam | 2019/20 |
| 2-188 | CL Vincent | South Africa v England | Kennington Oval, Kennington | 1935 |
| 3-184 | PR Adams | South Africa v Sri Lanka | Galle International Stadium, Galle | 2000 |
| 1-182 | PL Harris | South Africa v India | Eden Gardens, Kolkata | 2009/10 |
| 0-180 | Imran Tahir | South Africa v Australia | Adelaide Oval, Adelaide | 2012/13 |
| 5-180 | KA Maharaj | South Africa v England | St George's Park, Port Elizabeth | 2019/20 |
| 3-175 | K Rabada | South Africa v England | PPC Newlands, Cape Town | 2015/16 |
| 1-174 | N Gordon | South Africa v England | Kingsmead, Durban | 1938/39 |
| 1-174 | AMB Rowan | South Africa v England | Lord's Cricket Ground, St John's Wood | 1947 |
| 5-174 | AMB Rowan | South Africa v England | Headingley, Leeds | 1951 |
| 4-169 | ARA Murray | South Africa v Australia | Sydney Cricket Ground, Sydney | 1952/53 |
| 1-168 | RO Schwarz | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 1910/11 |
| 5-167 | AMB Rowan | South Africa v England | St George's Park, Port Elizabeth | 1948/49 |
| 2-165 | PL Harris | South Africa v West Indies | Warner Park, Basseterre | 2010 |
| 4-165 | XC Balaskas | South Africa v Australia | Old Wanderers, Johannesburg | 1935/36 |
| 1-163 | PR Adams | South Africa v Australia | New Wanderers Stadium, Johannesburg | 1996/97 |
| 1-163 | N Boje | South Africa v England | Sahara Stadium Kingsmead, Durban | 2004/05 |
| 4-162 | M Ntini | South Africa v New Zealand | Sahara Park Newlands, Cape Town | 2005/06 |
| 2-160 | KA Maharaj | South Africa v England | PPC Newlands, Cape Town | 2019/20 |
| 1-157 | XC Balaskas | South Africa v Australia | Kingsmead, Durban | 1935/36 |
| 5-157 | N Gordon | South Africa v England | Newlands, Cape Town | 1938/39 |
| 1-155 | AMB Rowan | South Africa v England | Ellis Park, Johannesburg | 1948/49 |
| 2-154 | NBF Mann | South Africa v Australia | St George's Park, Port Elizabeth | 1949/50 |
| 3-154 | KA Maharaj | South Africa v Sri Lanka | Sinhalese Sports Club Ground, Colombo | 2018 |
| 4-154 | CL Vincent | South Africa v Australia | Melbourne Cricket Ground, Melbourne | 1931/32 |
| 1-153 | N Boje | South Africa v Australia | New Wanderers Stadium, Johannesburg | 2001/02 |
| 5-153 | DL Piedt | South Africa v England | Sahara Stadium Kingsmead, Durban | 2015/16 |
