| Runs |
Out of |
4s |
6s |
| 90 | 97* | 6 | 11 | | E Lewis | St Kitts and Nevis Patriots v Barbados Tridents | Kensington Oval, Bridgetown | 2017 |
| 86 | 102* | 5 | 11 | | E Lewis | St Kitts and Nevis Patriots v Trinbago Knight Riders | Warner Park, Basseterre | 2021 |
| 82 | 100* | 7 | 9 | | E Lewis | St Kitts and Nevis Patriots v St Lucia Kings | Warner Park, Basseterre | 2024 |
| 68 | 93 | 5 | 8 | | CH Gayle | St Kitts and Nevis Patriots v Trinbago Knight Riders | Warner Park, Basseterre | 2017 |
| 66 | 92 | 6 | 7 | | KR Mayers | St Kitts and Nevis Patriots v St Lucia Kings | Warner Park, Basseterre | 2024 |
| 70 | 81 | 4 | 9 | | ADS Fletcher | St Kitts and Nevis Patriots v Guyana Amazon Warriors | Warner Park, Basseterre | 2024 |
| 60 | 82 | 6 | 6 | | E Lewis | St Kitts and Nevis Patriots v Jamaica Tallawahs | Warner Park, Basseterre | 2015 |
| 64 | 79 | 4 | 8 | | E Lewis | St Kitts and Nevis Patriots v Trinbago Knight Riders | Central Broward Regional Park Stadium Turf Ground, Lauderhill | 2016 |
| 62 | 92 | 5 | 7 | | E Lewis | St Kitts and Nevis Patriots v St Lucia Stars | Daren Sammy National Cricket Stadium, Gros Islet | 2017 |
| 58 | 86 | 7 | 5 | | CH Gayle | St Kitts and Nevis Patriots v Guyana Amazon Warriors | Guyana National Stadium, Providence | 2018 |
| 50 | 81 | 11 | 1 | | ADS Fletcher | St Kitts and Nevis Patriots v Barbados Royals | Warner Park, Basseterre | 2022 |
| 54 | 73 | 6 | 5 | | E Lewis | St Kitts and Nevis Patriots v St Lucia Zouks | Warner Park, Basseterre | 2016 |
| 56 | 69 | 5 | 6 | | E Lewis | St Kitts and Nevis Patriots v Jamaica Tallawahs | Warner Park, Basseterre | 2017 |
| 50 | 71 | 8 | 3 | | DC Thomas | St Kitts and Nevis Patriots v Jamaica Tallawahs | Warner Park, Basseterre | 2019 |
| 46 | 64 | 10 | 1 | | LJ Evans | St Kitts and Nevis Patriots v Barbados Tridents | Warner Park, Basseterre | 2019 |
| 56 | 65 | 5 | 6 | | E Lewis | St Kitts and Nevis Patriots v St Lucia Zouks | Warner Park, Basseterre | 2019 |
| 62 | 89 | 2 | 9 | | E Lewis | St Kitts and Nevis Patriots v Barbados Tridents | Queen's Park Oval, Port of Spain | 2020 |
| 56 | 73 | 5 | 6 | | E Lewis | St Kitts and Nevis Patriots v St Lucia Kings | Warner Park, Basseterre | 2021 |
| 60 | 77* | 3 | 8 | | E Lewis | St Kitts and Nevis Patriots v Guyana Amazon Warriors | Warner Park, Basseterre | 2021 |
| 54 | 78 | 6 | 5 | | SE Rutherford | St Kitts and Nevis Patriots v Trinbago Knight Riders | Guyana National Stadium, Providence | 2022 |
| 54 | 93* | 6 | 5 | | ADS Fletcher | St Kitts and Nevis Patriots v St Lucia Kings | Brian Lara Stadium, Tarouba | 2023 |
| 50 | 60 | 8 | 3 | | KR Mayers | St Kitts and Nevis Patriots v Trinbago Knight Riders | Guyana National Stadium, Providence | 2024 |
| 42 | 58 | 9 | 1 | | DC Thomas | St Kitts and Nevis Patriots v Trinbago Knight Riders | Queen's Park Oval, Port of Spain | 2018 |
| 48 | 64* | 6 | 4 | | FA Allen | St Kitts and Nevis Patriots v Barbados Tridents | Warner Park, Basseterre | 2018 |
| 48 | 64 | 6 | 4 | | CR Brathwaite | St Kitts and Nevis Patriots v Trinbago Knight Riders | Warner Park, Basseterre | 2019 |
| 46 | 62* | 7 | 3 | | FA Allen | St Kitts and Nevis Patriots v Jamaica Tallawahs | Sabina Park, Kingston | 2019 |
| 50 | 65* | 5 | 5 | | SE Rutherford | St Kitts and Nevis Patriots v Barbados Royals | Kensington Oval, Bridgetown | 2023 |
| 52 | 93 | 4 | 6 | | ADS Fletcher | St Kitts and Nevis Patriots v Trinbago Knight Riders | Guyana National Stadium, Providence | 2024 |
| 42 | 71* | 6 | 3 | | MN Samuels | St Kitts and Nevis Patriots v Barbados Tridents | Warner Park, Basseterre | 2015 |
| 46 | 60 | 4 | 5 | | BA King | St Kitts and Nevis Patriots v Barbados Tridents | Kensington Oval, Bridgetown | 2018 |
| 40 | 62 | 7 | 2 | | DC Thomas | St Kitts and Nevis Patriots v Guyana Amazon Warriors | Guyana National Stadium, Providence | 2019 |
| 48 | 53 | 3 | 6 | | E Lewis | St Kitts and Nevis Patriots v Jamaica Tallawahs | Warner Park, Basseterre | 2019 |
| 46 | 62 | 4 | 5 | | E Lewis | St Kitts and Nevis Patriots v Guyana Amazon Warriors | Warner Park, Basseterre | 2021 |
| 46 | 62* | 4 | 5 | | SE Rutherford | St Kitts and Nevis Patriots v Trinbago Knight Riders | Warner Park, Basseterre | 2023 |
| 44 | 63 | 5 | 4 | | WCF Smeed | St Kitts and Nevis Patriots v Barbados Royals | Kensington Oval, Bridgetown | 2023 |
| 40 | 56 | 7 | 2 | | M Louis | St Kitts and Nevis Patriots v Trinbago Knight Riders | Warner Park, Basseterre | 2024 |
| 50 | 63 | 2 | 7 | | M Louis | St Kitts and Nevis Patriots v Antigua and Barbuda Falcons | Warner Park, Basseterre | 2024 |
