| Runs |
Out of |
4s |
6s |
| 82 | 121* | 10 | 7 | | SPD Smith | Sydney Sixers v Perth Scorchers | Sydney Cricket Ground, Sydney | 2024/25 |
| 72 | 101* | 12 | 4 | | JM Vince | Sydney Sixers v Melbourne Stars | Sydney Cricket Ground, Sydney | 2024/25 |
| 62 | 98* | 14 | 1 | | JM Vince | Sydney Sixers v Perth Scorchers | Manuka Oval, Canberra | 2020/21 |
| 62 | 81* | 11 | 3 | | JR Philippe | Sydney Sixers v Perth Scorchers | Sydney Cricket Ground, Sydney | 2019/20 |
| 74 | 125* | 5 | 9 | | SPD Smith | Sydney Sixers v Sydney Thunder | Sydney Cricket Ground, Sydney | 2022/23 |
| 66 | 96 | 6 | 7 | | DP Hughes | Sydney Sixers v Melbourne Stars | Carrara Oval, Carrara | 2020/21 |
| 58 | 95 | 10 | 3 | | JM Vince | Sydney Sixers v Perth Scorchers | Sydney Cricket Ground, Sydney | 2020/21 |
| 56 | 99* | 11 | 2 | | JR Philippe | Sydney Sixers v Melbourne Stars | Melbourne Cricket Ground, Melbourne | 2021/22 |
| 58 | 85 | 7 | 5 | | NJ Maddinson | Sydney Sixers v Adelaide Strikers | Adelaide Oval, Adelaide | 2014/15 |
| 54 | 61 | 9 | 3 | | NJ Maddinson | Sydney Sixers v Melbourne Stars | Sydney Cricket Ground, Sydney | 2017/18 |
| 54 | 86* | 9 | 3 | | JR Philippe | Sydney Sixers v Hobart Hurricanes | Sydney Cricket Ground, Sydney | 2018/19 |
| 54 | 95 | 9 | 3 | | JR Philippe | Sydney Sixers v Melbourne Renegades | Blundstone Arena, Hobart | 2020/21 |
| 52 | 98* | 10 | 2 | | HL Kerr | Sydney Sixers v Adelaide Strikers | Sydney Cricket Ground, Sydney | 2021/22 |
| 62 | 101 | 5 | 7 | | SPD Smith | Sydney Sixers v Adelaide Strikers | International Sports Stadium, Coffs Harbour | 2022/23 |
| 48 | 79 | 12 | 0 | | JM Vince | Sydney Sixers v Melbourne Stars | Melbourne Cricket Ground, Melbourne | 2023/24 |
| 52 | 76* | 7 | 4 | | MC Henriques | Sydney Sixers v Sydney Thunder | Spotless Stadium, Sydney | 2016/17 |
| 52 | 85 | 7 | 4 | | DP Hughes | Sydney Sixers v Brisbane Heat | Brisbane Cricket Ground, Woolloongabba, Brisbane | 2016/17 |
| 54 | 62 | 6 | 5 | | NJ Maddinson | Sydney Sixers v Melbourne Stars | Melbourne Cricket Ground, Melbourne | 2017/18 |
| 46 | 84 | 10 | 1 | | JR Philippe | Sydney Sixers v Perth Scorchers | Manuka Oval, Canberra | 2020/21 |
| 50 | 76* | 8 | 3 | | MC Henriques | Sydney Sixers v Melbourne Stars | Sydney Cricket Ground, Sydney | 2021/22 |
| 50 | 83 | 8 | 3 | | JR Philippe | Sydney Sixers v Melbourne Stars | Sydney Cricket Ground, Sydney | 2021/22 |
| 52 | 66 | 7 | 4 | | BJ Dwarshuis | Sydney Sixers v Perth Scorchers | Marvel Stadium, Melbourne | 2021/22 |
| 48 | 91* | 9 | 2 | | JM Vince | Sydney Sixers v Melbourne Stars | Melbourne Cricket Ground, Melbourne | 2022/23 |
| 50 | 76 | 5 | 5 | | BJ Haddin | Sydney Sixers v Brisbane Heat | Sydney Cricket Ground, Sydney | 2011/12 |
| 48 | 70 | 6 | 4 | | MC Henriques | Sydney Sixers v Perth Scorchers | Western Australia Cricket Association Ground, Perth | 2011/12 |
| 48 | 61 | 6 | 4 | | NJ Maddinson | Sydney Sixers v Sydney Thunder | Sydney Cricket Ground, Sydney | 2013/14 |
| 52 | 84* | 4 | 6 | | NJ Maddinson | Sydney Sixers v Melbourne Renegades | Sydney Cricket Ground, Sydney | 2014/15 |
| 46 | 67 | 7 | 3 | | JC Silk | Sydney Sixers v Adelaide Strikers | Sydney Cricket Ground, Sydney | 2014/15 |
| 44 | 72 | 8 | 2 | | BJ Haddin | Sydney Sixers v Hobart Hurricanes | Sydney Cricket Ground, Sydney | 2015/16 |
| 56 | 72 | 2 | 8 | | MC Henriques | Sydney Sixers v Melbourne Stars | Sydney Cricket Ground, Sydney | 2019/20 |
| 44 | 67 | 8 | 2 | | JM Vince | Sydney Sixers v Hobart Hurricanes | Blundstone Arena, Hobart | 2020/21 |
| 44 | 78 | 8 | 2 | | JC Silk | Sydney Sixers v Hobart Hurricanes | Melbourne Cricket Ground, Melbourne | 2020/21 |
| 52 | 66 | 4 | 6 | | SPD Smith | Sydney Sixers v Hobart Hurricanes | Blundstone Arena, Hobart | 2022/23 |
| 44 | 83 | 8 | 2 | | JM Vince | Sydney Sixers v Melbourne Stars | Sydney Cricket Ground, Sydney | 2023/24 |
