| 160* | AC Voges | Middlesex v Hampshire | 2016 | f57143 |
| 154 | SD Robson | Middlesex v Leicestershire | 2021 | f60475 |
| 151 | MDE Holden | Middlesex v Northamptonshire | 2025 | f63033 |
| 147 | DJ Malan | Middlesex v Hampshire | 2016 | f57143 |
| 135 | SD Robson | Middlesex v Durham Marylebone Cricket Club University | 2018 | f58624 |
| 134 | SS Eskinazi | Middlesex v Durham Marylebone Cricket Club University | 2018 | f58624 |
| 126* | SD Robson | Middlesex v Northamptonshire | 2023 | f61648 |
| 125 | SS Eskinazi | Middlesex v Oxford Marylebone Cricket Club University | 2019 | f59409 |
| 117 | SD Robson | Middlesex v Durham Marylebone Cricket Club University | 2012 | f53975 |
| 114 | SM Whiteman | Northamptonshire v Middlesex | 2023 | f61648 |
| 114 | KS Williamson | Middlesex v Northamptonshire | 2025 | f63033 |
| 113 | EJ Pollock | Worcestershire v Middlesex | 2022 | f60920 |
| 105 | NRT Gubbins | Middlesex v Oxford Marylebone Cricket Club University | 2019 | f59409 |
| 105* | JL du Plooy | Middlesex v Northamptonshire | 2025 | f63033 |
| 100* | JA Simpson | Middlesex v Hampshire | 2016 | f57143 |
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