| 25 Jul 2021 | Royal London Cup 2021 | Essex v Middlesex | The Cloudfm County Ground, Chelmsford | Lost by 9 wkts |
| 27 Jul 2021 | Royal London Cup 2021 | Middlesex v Durham | Brunton Memorial Ground, Radlett | Lost by 2 runs |
| 30 Jul 2021 | Royal London Cup 2021 | Middlesex v Hampshire | Brunton Memorial Ground, Radlett | Abandoned |
| 01 Aug 2021 | Royal London Cup 2021 | Worcestershire v Middlesex | County Ground, New Road, Worcester | Won by 13 runs |
| 03 Aug 2021 | Royal London Cup 2021 | Lancashire v Middlesex | Emirates Old Trafford, Manchester | Won by 6 runs |
| 06 Aug 2021 | Royal London Cup 2021 | Middlesex v Kent | Brunton Memorial Ground, Radlett | Lost by 21 runs |
| 08 Aug 2021 | Royal London Cup 2021 | Middlesex v Gloucestershire | Brunton Memorial Ground, Radlett | Cancelled |
| 12 Aug 2021 | Royal London Cup 2021 | Sussex v Middlesex | The 1st Central County Ground, Hove | Lost by 3 runs |
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